"Desgagné-Penix, I."

Article

Jayawardena, T. U., Merindol, N., Liyanage, N. S., Gélinas, S. E., Lionel, B., Seydou, K., Seck, M., Evidente, A. et Desgagné-Penix, I. (2025). Antiviral alkaloids from Crinum jagus: Extraction, synergistic effects, and activity against dengue virus and human coronavirus OC43. Heliyon, 11 (4). Article e42580. ISSN 2405-8440 DOI 10.1016/j.heliyon.2025.e42580

Niraula, A., Danesh, A., Merindol, N., Meddeb-Mouelhi, F. et Desgagné-Penix, I. (2025). Aromatic amino acids: Exploring microalgae as a potential biofactory. BioTech, 14 (1). Article 6. ISSN 2673-6284 DOI 10.3390/biotech14010006

Lamichhane, B., Gélinas, S.-E., Merindol, N., Koirala, M., dos Santos, K. C. G., Germain, H. et Desgagné-Penix, I. (2025). Elucidating the enzyme network driving Amaryllidaceae alkaloids biosynthesis in Leucojum aestivum. Plant Biotechnology Journal . ISSN 1467-7644 DOI 10.1111/pbi.70026

Fantino, E., Messaabi, A., Mérindol, N., Awwad, F., Sene, N., Gélinas, S. E., Custeau, A., Rhéaume, K. L., Meddeb-Mouelhi, F. et Desgagné-Penix, I. (2025). Extrachromosomal expression of functional Cannabis sativa cannabidiolic acid synthase in Phaedodactylum tricornutum. Algal Research, 85 . Article 103889. ISSN 2211-9264 DOI 10.1016/j.algal.2024.103889

Jayawardena, T. U., Merindol, N., Liyanage, N. S., Awwad, F. et Desgagné-Penix, I. (2025). Marine specialized metabolites: Unveiling Nature's chemical treasures from the deep blue. TrAC - Trends in Analytical Chemistry, 183 . Article 118097. ISSN 0165-9936 1879-3142 DOI 10.1016/j.trac.2024.118097

Augustine, A., Messaabi, A., Fantino, E., Merindol, N., Meddeb-Mouelhi, F. et Desgagné-Penix, I. (2025). Multifactorial interaction and influence of culture conditions on yellow fluorescent protein production in Phaeodactylum tricornutum. Bioresource Technology, 425 . Article 132336. ISSN 0960-8524 1873-2976 DOI 10.1016/j.biortech.2025.132336

Tazon, A. W., Awwad, F., Meddeb-Mouelhi, F. et Desgagné-Penix, I. (2024). Biotechnological advances in vanillin production: From natural vanilla to metabolic engineering platforms. BioChem, 4 (4). pp. 323-349. ISSN 2673-6411 DOI 10.3390/biochem4040017

Karimzadegan, V., Koirala, M., Sobhanverdi, S., Merindol, N., Majhi, B. B., Gélinas, S. E., Timokhin, V. I., Ralph, J., Dastmalchi, M. et Desgagné-Penix, I. (2024). Characterization of cinnamate 4-hydroxylase (CYP73A) and p-coumaroyl 3′-hydroxylase (CYP98A) from Leucojum aestivum, a source of Amaryllidaceae alkaloids. Plant Physiology and Biochemistry, 210 . Article 108612. ISSN 0981-9428 1873-2690 DOI 10.1016/j.plaphy.2024.108612

Jaramillo Jimenez, B. A., Awwad, F. et Desgagné-Penix, I. (2024). Cinnamaldehyde in focus: Antimicrobial properties, biosynthetic pathway, and industrial applications. Antibiotics, 13 (11). Article 1095. ISSN 2079-6382 DOI 10.3390/antibiotics13111095

Messaabi, A., Merindol, N., Bohnenblust, L., Fantino, E., Meddeb-Mouelhi, F. et Desgagné-Penix, I. (2024). In vivo thrombin activity in the diatom Phaeodactylum tricornutum: Biotechnological insights. Applied Microbiology and Biotechnology, 108 (1). Article 481. ISSN 0175-7598 1432-0614 DOI 10.1007/s00253-024-13322-z

Koirala, M., Merindol, N., Karimzadegan, V., Gélinas, S. E., Liyanage, N. S., Lamichhane, B., Tobón, M. C. G., Lagüe, P. et Desgagné-Penix, I. (2024). Kinetic and in silico structural characterization of norbelladine O-methyltransferase of Amaryllidaceae alkaloids biosynthesis. Journal of Biological Chemistry, 300 (9). Article 107649. ISSN 0021-9258 1083-351X DOI 10.1016/j.jbc.2024.107649

Liyanage, N. S., Awwad, F., Gonçalves Dos Santos, K. C., Jayawardena, T. U., Merindol, N. et Desgagné-Penix, I. (2024). Navigating Amaryllidaceae alkaloids: Bridging gaps and charting biosynthetic territories. Journal of Experimental Botany, 76 (1). pp. 16-34. ISSN 0022-0957 1460-2431 DOI 10.1093/jxb/erae187

Diaz-Garza, A. M., Merindol, N., dos Santos, K. C. G., Lavoie-Marchand, F., Ingalls, B. et Desgagné-Penix, I. (2024). No two clones are alike: characterization of heterologous subpopulations in a transgenic cell line of the model diatom Phaeodactylum tricornutum. Microbial Cell Factories, 23 (1). Article 286. ISSN 1475-2859 DOI 10.1186/s12934-024-02559-y

Friedhoff, R., Elfayres, G., Mérindol, N., Desgagné-Penix, I. et Berthoux, L. (2024). RNA replication-independent, DNA linearization-dependent expression of reporter genes from a SARS-CoV-2 replicon-encoding DNA in human cells. PLoS ONE, 19 (8). Article e0300491. ISSN 1932-6203 DOI 10.1371/journal.pone.0300491

Gagné, V., Merindol, N., Boucher, R., Boucher, N. et Desgagné-Penix, I. (2024). Rooted in therapeutics: Comprehensive analyses of Cannabis sativa root extracts reveals potent antioxidant, anti-inflammatory, and bactericidal properties. Frontiers in Pharmacology, 15 . Article 1465136. ISSN 1663-9812 DOI 10.3389/fphar.2024.1465136

Beauchemin, R., Merindol, N., Fantino, E., Lavoie, P., Nouemssi, S. B., Meddeb-Mouelhi, F. et Desgagné-Penix, I. (2024). Successful reversal of transgene silencing in Chlamydomonas reinhardtii. Biotechnology Journal, 19 (1). Article 2300232. ISSN 1860-6768 1860-7314 DOI 10.1002/biot.202300232

Hashemian, S. M., Merindol, N., Paquin, A., Singh, A., Berthoux, L., Daoust, B. et Desgagné-Penix, I. (2024). Synthesis, characterization, and biological evaluation of N-methyl derivatives of norbelladine. Molecules, 29 (18). Article 4442. ISSN 1420-3049 DOI 10.3390/molecules29184442

Jayawardena, T. U., Merindol, N., Liyanage, N. S. et Desgagné-Penix, I. (2024). Unveiling Amaryllidaceae alkaloids: From biosynthesis to antiviral potential - a review. Natural Product Reports, 41 (5). pp. 721-747. ISSN 0265-0568 1460-4752 DOI 10.1039/D3NP00044C

Awwad, F., Fantino, E. I., Héneault, M., Diaz-Garza, A. M., Merindol, N., Custeau, A., Gélinas, S. E., Meddeb-Mouelhi, F., Li, J., Lemay, J. F., Karas, B. J. et Desgagné-Penix, I. (2023). Bioengineering of the marine diatom Phaeodactylum tricornutum with cannabis genes enables the production of the cannabinoid precursor, olivetolic acid. International Journal of Molecular Sciences, 24 (23). Article 16624. ISSN 1661-6596 1422-0067 DOI 10.3390/ijms242316624

Majhi, B. B., Gélinas, S. E., Mérindol, N., Ricard, S. et Desgagné-Penix, I. (2023). Characterization of norbelladine synthase and noroxomaritidine/norcraugsodine reductase reveals a novel catalytic route for the biosynthesis of Amaryllidaceae alkaloids including the Alzheimer’s drug galanthamine. Frontiers in Plant Science, 14 . Article 1231809. ISSN 1664-462X DOI 10.3389/fpls.2023.1231809

Sharma, N., Fantino, E. I., Awwad, F., Mérindol, N., Augustine, A., Meddeb, F. et Desgagné-Penix, I. (2023). Impact of different light characteristics on the growth and lipid content of diatom Phaeodactylum tricornutum transconjugant strains. American Journal of Plant Sciences, 14 (1). pp. 41-63. ISSN 2158-2742 2158-2750 DOI 10.4236/ajps.2023.141004

Diamond, A., Diaz-Garza, A. M., Li, J., Slattery, S. S., Merindol, N., Fantino, E., Meddeb-Mouelhi, F., Karas, B. J., Barnabé, S. et Desgagné-Penix, I. (2023). Instability of extrachromosomal DNA transformed into the diatom Phaeodactylum tricornutum. Algal Research, 70 . Article 102998. ISSN 2211-9264 DOI 10.1016/j.algal.2023.102998

Diamond, A., Barnabé, S. et Desgagné-Penix, I. (2023). Is a spice missing from the recipe? The intra-cellular localization of vanillin biosynthesis needs further investigations. Plant Biology, 25 (1). pp. 3-7. ISSN 1435-8603 1438-8677 DOI 10.1111/plb.13465

Di Lecce, R., Mérindol, N., Pérez, M. G., Karimzadegan, V., Berthoux, L., Boari, A., Zidorn, C., Vurro, M., Surico, G., Desgagné-Penix, I. et Evidente, A. (2022). Biochemical analyses of bioactive extracts from plants native to Lampedusa, Sicily Minor Island. Plants, 11 (24). Article 3447. ISSN 2223-7747 DOI 10.3390/plants11243447

Koirala, M., Karimzadegan, V., Liyanage, N. S., Mérindol, N. et Desgagné-Penix, I. (2022). Biotechnological approaches to optimize the production of Amaryllidaceae alkaloids. Biomolecules, 12 (7). Article 893. ISSN 2218-273X DOI 10.3390/biom12070893

Girard, M. P., Karimzadegan, V., Héneault, M., Cloutier, F., Bérubé, G., Berthoux, L., Mérindol, N. et Desgagné-Penix, I. (2022). Chemical synthesis and biological activities of Amaryllidaceae alkaloid norbelladine derivatives and precursors. Molecules, 27 (17). Article 5621. ISSN 1420-3049 DOI 10.3390/molecules27175621

Masi, M., Di Lecce, R., Mérindol, N., Girard, M. P., Berthoux, L., Desgagné-Penix, I., Calabrò, V. et Evidente, A. (2022). Cytotoxicity and antiviral properties of alkaloids isolated from Pancratium maritimum. Toxins, 14 (4). Article 262. ISSN 2072-6651 DOI 10.3390/toxins14040262

Ka, S., Merindol, N., Sow, A. A., Singh, A., Landelouci, K., Plourde, M. B., Pépin, G., Masi, M., Di Lecce, R., Evidente, A., Seck, M., Berthoux, L., Chatel-Chaix, L. et Desgagné-Penix, I. (2021). Amaryllidaceae alkaloid cherylline inhibits the replication of dengue and Zika viruses. Antimicrobial Agents and Chemotherapy, 65 (9). Article 00398-21. ISSN 0066-4804 1098-6596 DOI 10.1128/aac.00398-21

Ka, S., Mérindol, N., Seck, I., Ricard, S., Diop, A., Boye, C. S. B., Landelouci, K., Daoust, B., Berthoux, L., Pépin, G., Seck, M. et Desgagné-Penix, I. (2021). Biological investigation of amaryllidaceae alkaloid extracts from the bulbs of pancratium trianthum collected in the Senegalese flora. Molecules, 26 (23). Article 7382. ISSN 1420-3049 DOI 10.3390/molecules26237382

Boivin, M., Bourdeau, N., Barnabé, S. et Desgagné-Penix, I. (2021). Black spruce extracts reveal antimicrobial and sprout suppressive potentials to prevent potato (Solanum tuberosum L.) losses during storage. Journal of Agriculture and Food Research, 5 . Article 100187. ISSN 2666-1543 DOI 10.1016/j.jafr.2021.100187

dos Santos, K. C. G., Desgagné-Penix, I. et Germain, H. (2021). Correction to: Custom selected reference genes outperform pre-defined reference genes in transcriptomic analysis. BMC Genomics, 22 (1). p. 607. ISSN 1471-2164 DOI 10.1186/s12864-021-07743-7

Sharma, N., Simon, D. P., Diaz-Garza, A. M., Fantino, E., Messaabi, A., Meddeb-Mouelhi, F., Germain, H. et Desgagné-Penix, I. (2021). Diatoms biotechnology: various industrial applications for a greener tomorrow. Frontiers in Marine Science, 8 (106). ISSN 2296-7745 DOI 10.3389/fmars.2021.636613

dos Santos, K. C. G., Pelletier, G., Séguin, A., Guillemette, F., Hawkes, J., Desgagné-Penix, I. et Germain, H. (2021). Unrelated fungal rust candidate effectors act on overlapping plant functions. Microorganisms, 9 (5). ISSN 2076-2607 DOI 10.3390/microorganisms9050996

Blondeau, D., St-Pierre, A., Bourdeau, N., Bley, J., Lajeunesse, A. et Desgagné-Penix, I. (2020). Antimicrobial activity and chemical composition of white birch (Betula papyrifera Marshall) bark extracts. MicrobiologyOpen, 9 (1). Article e00944. ISSN 2045-8827 DOI 10.1002/mbo3.944

Ka, S., Koirala, M., Mérindol, N. et Desgagné-Penix, I. (2020). Biosynthesis and biological activities of newly discovered Amaryllidaceae alkaloids. Molecules, 25 (21). Article 4901. ISSN 1420-3049 DOI 10.3390/molecules25214901

Dhaouadi, F., Awwad, F., Diamond, A. et Desgagné-Penix, I. (2020). Diatoms’ breakthroughs in biotechnology: Phaeodactylum tricornutum as a model for producing high-added value molecules. American Journal of Plant Sciences, 11 (10). pp. 1632-1670. ISSN 2158-2742 2158-2750 DOI 10.4236/ajps.2020.1110118

Ghribi, M., Nouemssi, S. B., Meddeb-Mouelhi, F. et Desgagné-Penix, I. (2020). Genome editing by CRISPR-Cas: A game change in the genetic manipulation of chlamydomonas. Life, 10 (11). Article 295. ISSN 2075-1729 DOI 10.3390/life10110295

Sharma, N., Fleurent, G., Awwad, F., Cheng, M., Meddeb-Mouelhi, F., Budge, S. M., Germain, H. et Desgagné-Penix, I. (2020). Red light variation an effective alternative to regulate biomass and lipid profiles in phaeodactylum tricornutum. Applied Sciences, 10 (7). Article 2531. ISSN 2076-3417 DOI 10.3390/app10072531

Beaupré, V., Boucher, N. et Desgagné-Penix, I. (2020). Thykamine extracts from spinach reduce acute inflammation in vivo and downregulate phlogogenic functions of human blood neutrophils in vitro. Biomedicines, 8 (7). Article 219. ISSN 2227-9059 DOI 10.3390/biomedicines8070219

Fradj, N., Gonçalves Dos Santos, K. C., de Montigny, N., Awwad, F., Boumghar, Y., Germain, H. et Desgagné-Penix, I. (2019). RNA-Seq de Novo Assembly and Differential Transcriptome Analysis of Chaga (Inonotus obliquus) Cultured with Different Betulin Sources and the Regulation of Genes Involved in Terpenoid Biosynthesis. International Journal of Molecular Sciences, 20 (18). ISSN 1422-0067 DOI 10.3390/ijms20184334

Ahmed, M. B., Santos, K. C. G., Sanchez, I. B., Petre, B., Lorrain, C., Plourde, M. B., Duplessis, S., Desgagné-Penix, I. et Germain, H. (2018). A rust fungal effector binds plant DNA and modulates transcription. Scientific Reports, 8 (1). ISSN 2045-2322 DOI 10.1038/s41598-018-32825-0