Specific structural changes in Parkinson’s disease-related olfactory dysfunction compared to others forms of olfactory dysfunction

Brosse, S., Tremblay, C., Mérida, I. et Frasnelli, J. (2024). Specific structural changes in Parkinson’s disease-related olfactory dysfunction compared to others forms of olfactory dysfunction. Frontiers in Neural Circuits, 18 . Article 1503841. ISSN 1662-5110 DOI 10.3389/fncir.2024.1503841

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Résumé

Abstract
Context:
Olfactory dysfunction (OD) is a common early symptom of Parkinson’s disease (PD). However, OD is not specific to PD, as approximatively 20% of the general population exhibit different forms of OD. To use olfactory measures for early Parkinson screening, it is crucial to distinguish PD-related OD from Non-Parkinsonian OD (NPOD).

Objectives and hypothesis:
This study aimed to compare the structural changes associated with PD-related OD (n = 15) with NPOD (n = 15), focusing on gray matter volumes and white matter fiber integrity in chemosensory regions. We hypothesized that PD-related OD presents specific structural alterations in these regions.

Methods:
Participants underwent a 3 T MRI scan, which included anatomical T1 and diffusion-weighted imaging. Gray and white matter integrity were assessed using both whole-brain analyses (voxel-based morphometry—VBM and tract-based spatial statistics—TBSS, respectively) and localized approaches, including regions of interest and tractography.

Results:
PD patients exhibited significantly higher gray matter volume in the left insula using restricted regions-of-interest analyses, while no other significant gray or white matter differences were found between groups.

Conclusion:
Structural imaging of the gray matter, particularly the insula, but not of white matter, differentiates PD-related OD from NPOD.

Type de document:	Article
Mots-clés libres:	Parkinson’s disease Olfactory dysfunction Trigeminal system Gray matter White matter Insula
Date de dépôt:	19 févr. 2026 16:39
Dernière modification:	19 févr. 2026 16:39
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/12635

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