Perspectives on antibiotic management of diabetic foot osteomyelitis: A scoping review on routes of administration

Meddas, N., Gachet, B., Piraux, A., Senneville, E., Drudi, L. M., Brousseau-Foley, M. et Blanchette, V. (2026). Perspectives on antibiotic management of diabetic foot osteomyelitis: A scoping review on routes of administration. Diabetes Research and Clinical Practice, 231 . p. 113035. ISSN 0168-8227 DOI 10.1016/j.diabres.2025.113035

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Résumé

Diabetic foot ulcers can progress to diabetic foot osteomyelitis (DFO). Intravenous (IV) antibiotics are traditionally the standard treatment for DFO, but it might reduce quality of life, increase adverse events and costs. Our objective was to examine the potential advantages and disadvantages of antibiotic administration routes for DFO to support a future patient decision aid tool. We conducted a scoping review using the Joanna Briggs Institute methodological framework to map evidence on antibiotic administration routes for DFO using the quintuple aim for quality of care. Records from databases, reference lists, and grey literature were deduplication in EndNote, screened in Rayyan, and assessed independently by two interdisciplinary reviewers. Of 6814, 25 studies were included, all quantitative and mainly retrospective observational (76 %). The majority (68 %) included adult patients with diabetic foot infection or DFO. Oral and IV antibiotics demonstrated comparable clinical outcomes across studies. Data on patient-reported outcomes and experience, team management, equity factors, and standardized definitions of clinical endpoints were largely scarce across studies. Current data suggest that oral antibiotic therapy may be a safe and effective alternative to IV therapy in selected patients with DFO, though substantial evidence gaps remain beyond infection management.

Type de document:	Article
Mots-clés libres:	Diabetic foot Osteomyelitis Administration, Intravenous Administration, Oral
Date de dépôt:	24 mars 2026 12:13
Dernière modification:	24 mars 2026 12:13
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/12679

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