Opportunities and pitfalls of REM sleep behavior disorder and olfactory dysfunction as early markers in parkinson's disease

Orso, B., Brosse, S., Frasnelli, J. et Arnaldi, D. (2024). Opportunities and pitfalls of REM sleep behavior disorder and olfactory dysfunction as early markers in parkinson's disease. Journal of Parkinson's Disease, 14 (s2). S275-S285. ISSN 1877-7171 1877-718X DOI 10.3233/JPD-230348

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Résumé

Abstract
During its pre-motor stage, Parkinson's disease (PD) presents itself with a multitude of non-motor symptoms with different degrees of specificity and sensitivity. The most important among them are REM sleep behavior disorder (RBD) and olfactory dysfunction. RBD is a parasomnia characterized by the loss of REM sleep muscle atonia and dream-enacting behaviors. Olfactory dysfunction in individuals with prodromal PD is usually described as hyposmia (reduced sense of smell) or anosmia (complete loss of olfactory function). These symptoms can precede the full expression of motor symptoms by decades. A close comprehension of these symptoms and the underlying mechanisms may enable early screening as well as interventions to improve patients' quality of life. Therefore, these symptoms have unmatched potential for identifying PD patients in prodromal stages, not only allowing early diagnosis but potentially opening a window for early, possibly disease-modifying intervention. However, they come with certain challenges. This review addresses some of the key opportunities and pitfalls of both RBD and olfactory dysfunction as early markers of PD.

Type de document:	Article
Mots-clés libres:	REM Sleep behavior disorder Hyposmia Anosmia Parkinson’s disease Early markers Screening
Date de dépôt:	19 févr. 2026 16:21
Dernière modification:	19 févr. 2026 16:21
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/12632

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