Verbal episodic memory alterations and hippocampal atrophy in acute mild traumatic brain injury

Fortier-Lebel, O., Jobin, B., Lécuyer-Giguère, F., Gaubert, M., Giguère, J. F., Gagnon, J. F., Boller, B. et Frasnelli, J. (2021). Verbal episodic memory alterations and hippocampal atrophy in acute mild traumatic brain injury. Journal of Neurotrauma, 38 (11). pp. 1506-1514. ISSN 0897-7151 1557-9042 DOI 10.1089/neu.2020.7475

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Résumé

Episodic memory deficit is a symptom frequently observed after a mild traumatic brain injury (mTBI). However, few studies have investigated the impact of a single and acute mTBI on episodic memory and structural cerebral changes. To do so, we conducted two experiments. In the first, we evaluated verbal episodic memory by using a word recall test, in 52 patients with mTBI (mean age 33.1 [12.2] years) 2-4 weeks after a first mTBI, compared with 54 healthy controls (31.3 [9.2] years) and followed both groups up for 6 months. In the second, we measured hippocampal volume in a subset of 40 participants (20 patients with mTBI, 20 controls) from Experiment 1 using magnetic resonance imaging (MRI; T1-weighted images) and correlated memory performance scores to hippocampal volume. Experiment 1 showed significantly reduced verbal episodic memory within the first month after an mTBI and a tendency for a reduction 6 months later, more pronounced for men. In Experiment 2, patients with mTBI exhibited a generally reduced hippocampal volume; however, we did not observe any linear correlation between hippocampal volume and memory scores. These results suggest that one single mTBI is associated with both episodic memory alteration and reduced volume of the hippocampus in the acute phase. Future studies are needed to elucidate the link between both measures.

Type de document:	Article
Mots-clés libres:	Hippocampus Hopkins Verbal Learning Test Magnetic resonance imaging Memory Mild traumatic brain injury Volumetry Adult Article Brain atrophy Brain size Controlled study Correlational study Episodic memory Female Groups by age Human Major clinical study Male Memory disorder Memory test Mental performance Nuclear magnetic resonance imaging Scoring system Traumatic brain injury Verbal memory Word recognition Atrophy Brain concussion Case control study Diagnostic imaging Follow up Organ size Pathology Physiology Psychology Time factor Verbal learning Young adult Case-Control Studies Follow-Up Studies Humans Memory Disorders Memory, Episodic Time Factors
Date de dépôt:	29 janv. 2026 13:23
Dernière modification:	29 janv. 2026 13:23
Version du document déposé:	Post-print (version corrigée et acceptée)
URI:	https://depot-e.uqtr.ca/id/eprint/12578

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