Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men

Cefis, M., Marcangeli, V., Hammad, R., Granet, J., Leduc-Gaudet, J.-P., Gaudreau, P., Trumpff, C., Huang, Q., Picard, M., Aubertin-Leheudre, M., Belanger, M., Robitaille, R., Morais, J. A. et Gouspillou, G. (2025). Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Cell Reports Medicine, 6 (2). Article 101968. ISSN 2666-3791 DOI 10.1016/j.xcrm.2025.101968

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Summary
Aging-related muscle atrophy and weakness contribute to loss of mobility, falls, and disability. Mitochondrial dysfunction is widely considered a key contributing mechanism to muscle aging. However, mounting evidence positions physical activity as a confounding factor, making unclear whether muscle mitochondria accumulate bona fide defects with aging. To disentangle aging from physical activity-related mitochondrial adaptations, we functionally profiled skeletal muscle mitochondria in 51 inactive and 88 active men aged 20–93. Physical activity status confers partial protection against age-related decline in physical performance. Mitochondrial respiration remains unaltered in active participants, indicating that aging per se does not alter mitochondrial respiratory capacity. Mitochondrial reactive oxygen species (ROS) production is unaffected by aging and higher in active participants. In contrast, mitochondrial calcium retention capacity decreases with aging regardless of physical activity and correlates with muscle mass, performance, and the stress-responsive metabokine/mitokine growth differentiation factor 15 (GDF15). Targeting mitochondrial calcium handling may hold promise for treating aging-related muscle impairments.

Type de document:	Article
Mots-clés libres:	Skeletal muscle aging Sarcopenia Mitochondria Muscle atrophy and weakness Calcium retention capacity Mitochondrial permeability transition pore Physical performance Functional capacities Intermuscular fat accumulation Reactive oxygen species
Date de dépôt:	17 sept. 2025 15:58
Dernière modification:	17 sept. 2025 15:58
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/12241

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