Exploring the lesser-known bioactive natural products of plant species of the genus cannabis L.: Alkaloids, phenolic compounds, and their therapeutic potential

Boucher, R., Germain, H. et Desgagné-Penix, I. (2025). Exploring the lesser-known bioactive natural products of plant species of the genus cannabis L.: Alkaloids, phenolic compounds, and their therapeutic potential. Plants, 14 (9). Article 1372. ISSN 2223-7747 DOI 10.3390/plants14091372

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Abstract
Plant species of the genus Cannabis L. are predominantly recognized for their cannabinoids, which have garnered significant attention due to their bioactive properties. However, Cannabis also produces a diverse array of bioactive compounds with promising pharmacological potential that remain underexplored. This review focuses primarily on phytochemicals derived from Cannabis sativa L. subspecies, including both its drug-type and fiber-type varieties, which are the most widely cultivated and studied within the genus. Among these, nitrogen-containing compounds such as spermidine alkaloids exhibit neuroprotective and anti-aging properties, while hydroxycinnamic acids and hydroxycinnamic acid amides, including N-trans-caffeoyltyramine and N-trans-feruloyltyramine, have demonstrated notable antioxidant and anti-inflammatory activities. Additionally, Cannabis species are a valuable source of unique stilbenes, such as canniprene, and flavonoids, including cannflavin A and B, which demonstrated potent anti-inflammatory and antiproliferative effects. Despite this rich phytochemical diversity, research on these compounds remains limited, largely due to historical legal restrictions. This literature review consolidates and updates current knowledge on these lesser-studied phytochemicals of Cannabis, detailing their biosynthetic pathways, metabolic precursors, and emerging therapeutic applications. By expanding the research focus beyond cannabinoids, this work aims to enhance our understanding of Cannabis’s full pharmacological potential and promote further investigation into its diverse chemical constituents.

Type de document:	Article
Mots-clés libres:	Nitrogen-containing compounds Spermidine-type alkaloids Non-cannabinoid metabolites Plant specialized metabolism Cannabisativin Flavonoids Stilbenes Cannflavins Cannabisins
Date de dépôt:	28 juill. 2025 15:30
Dernière modification:	28 juill. 2025 15:30
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/12168

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