Biological investigation of amaryllidaceae alkaloid extracts from the bulbs of pancratium trianthum collected in the Senegalese flora

Ka, S., Mérindol, N., Seck, I., Ricard, S., Diop, A., Boye, C. S. B., Landelouci, K., Daoust, B., Berthoux, L., Pépin, G., Seck, M. et Desgagné-Penix, I. (2021). Biological investigation of amaryllidaceae alkaloid extracts from the bulbs of pancratium trianthum collected in the Senegalese flora. Molecules, 26 (23). Article 7382. ISSN 1420-3049 DOI 10.3390/molecules26237382

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Résumé

Abstract

Amaryllidaceae plants are rich in alkaloids with biological properties. Pancratium trianthum is an Amaryllidaceae species widely used in African folk medicine to treat several diseases such as central nervous system disorders, tumors, and microbial infections, and it is used to heal wounds. The current investigation explored the biological properties of alkaloid extracts from bulbs of P. trianthum collected in the Senegalese flora. Alkaloid extracts were analyzed and identified by chromatography and mass spectrometry. Alkaloid extracts from P. trianthum displayed pleiotropic biological properties. Cytotoxic activity of the extracts was determined on hepatocarcinoma Huh7 cells and on acute monocytic leukemia THP-1 cells, while agar diffusion and microdilution assays were used to evaluate antibacterial activity. Antiviral activity was measured by infection of extract-treated cells with dengue virus (DENVGFP) and human immunodeficiency virus-1 (HIV-1GFP) reporter vectors. Cytotoxicity and viral inhibition were the most striking of P. trianthum’s extract activities. Importantly, noncytotoxic concentrations were highly effective in completely preventing DENVGFP replication and in reducing pseudotyped HIV-1GFP infection levels. Our results show that P. trianthum is a rich source of molecules for the potential discovery of new treatments against various diseases. Herein, we provide scientific evidence to rationalize the traditional uses of P. trianthum for wound treatment as an anti-dermatosis and antiseptic agent.

Type de document:	Article
Mots-clés libres:	Alkaloid Amaryllidaceae Pancratium trianthum Antiviral Antimicrobial Dengue virus HIV
Date de dépôt:	22 avr. 2025 15:20
Dernière modification:	22 avr. 2025 15:23
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/11888

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