Biosynthesis and biological activities of newly discovered Amaryllidaceae alkaloids

Ka, S., Koirala, M., Mérindol, N. et Desgagné-Penix, I. (2020). Biosynthesis and biological activities of newly discovered Amaryllidaceae alkaloids. Molecules, 25 (21). Article 4901. ISSN 1420-3049 DOI 10.3390/molecules25214901

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Abstract

Alkaloids are an important group of specialized nitrogen metabolites with a wide range of biochemical and pharmacological effects. Since the first publication on lycorine in 1877, more than 650 alkaloids have been extracted from Amaryllidaceae bulbous plants and clustered together as the Amaryllidaceae alkaloids (AAs) family. AAs are specifically remarkable for their diverse pharmaceutical properties, as exemplified by the success of galantamine used to treat the symptoms of Alzheimer’s disease. This review addresses the isolation, biological, and structure activity of AAs discovered from January 2015 to August 2020, supporting their therapeutic interest.

Type de document:	Article
Mots-clés libres:	Amaryllidaceae alkaloids Specialized metabolism Biosynthesis Antitumor Anti-cholinesterase Antiviral Antiparasitic
Date de dépôt:	22 avr. 2025 15:17
Dernière modification:	22 avr. 2025 15:17
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/11887

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