Biotechnological approaches to optimize the production of Amaryllidaceae alkaloids

Koirala, M., Karimzadegan, V., Liyanage, N. S., Mérindol, N. et Desgagné-Penix, I. (2022). Biotechnological approaches to optimize the production of Amaryllidaceae alkaloids. Biomolecules, 12 (7). Article 893. ISSN 2218-273X DOI 10.3390/biom12070893

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Résumé

Abstract

Amaryllidaceae alkaloids (AAs) are plant specialized metabolites with therapeutic properties exclusively produced by the Amaryllidaceae plant family. The two most studied representatives of the family are galanthamine, an acetylcholinesterase inhibitor used as a treatment of Alzheimer’s disease, and lycorine, displaying potent in vitro and in vivo cytotoxic and antiviral properties. Un-fortunately, the variable level of AAs’ production in planta restricts most of the pharmaceutical applications. Several biotechnological alternatives, such as in vitro culture or synthetic biology, are being developed to enhance the production and fulfil the increasing demand for these AAs plant-derived drugs. In this review, current biotechnological approaches to produce different types of bioactive AAs are discussed.

Type de document:	Article
Mots-clés libres:	Amaryllidaceae alkaloids Bioactive molecules Biotechnological approach Biosynthesis In vitro cultures Synthetic biology
Date de dépôt:	22 avr. 2025 15:09
Dernière modification:	22 avr. 2025 15:09
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/11885

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