Cinnamaldehyde in focus: Antimicrobial properties, biosynthetic pathway, and industrial applications

Jaramillo Jimenez, B. A., Awwad, F. et Desgagné-Penix, I. (2024). Cinnamaldehyde in focus: Antimicrobial properties, biosynthetic pathway, and industrial applications. Antibiotics, 13 (11). Article 1095. ISSN 2079-6382 DOI 10.3390/antibiotics13111095

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Résumé

Abstract

Trans-cinnamaldehyde (TCA), a major bioactive compound derived from cinnamon (Cinnamomum spp.), has garnered significant attention for its diverse therapeutic properties. Its broad-spectrum antimicrobial activity, targeting both Gram-positive and Gram-negative bacteria as well as various fungi, positions TCA as a potent natural antimicrobial agent. Beyond its antimicrobial effects, TCA demonstrates promising antidiabetic and anti-inflammatory activities, making it a valuable compound in medicinal and cosmetic applications. Recent studies have highlighted its role in disrupting microbial membranes, inhibiting biofilm formation, and modulating key metabolic pathways in pathogens. Furthermore, TCA has gained popularity in cosmetics due to its antimicrobial activity, antioxidant properties, and skin-friendly profile. This review provides a comprehensive overview of TCA’s antimicrobial potential, focusing on its mechanisms of action and its market and industrial applications. We also discuss the biosynthetic pathway of TCA, exploring both its natural production in cinnamon and advances in biotechnological production methods. As the demand for sustainable and natural antimicrobial agents grows, TCA emerges as a promising candidate for diverse applications. Finally, this review explores future directions for optimizing TCA production through metabolic engineering and synthetic biology approaches to meet industrial-scale demands. © 2024 by the authors.

Type de document:	Article
Mots-clés libres:	Antimicrobial Aromatic aldehydes Biosynthesis Production methods Specialized metabolism Trans-cinnamaldehyde Aldehyde Antidiabetic agent Antiinfective agent Antioxidant Cinnamaldehyde Antiinflammatory activity Antimicrobial activity Biofilm Biotechnological production Cinnamomum Cinnamomum zeylanicum Cinnamon Drug analysis Metabolic engineering Nonhuman Review Synthetic biology
Date de dépôt:	22 avr. 2025 20:47
Dernière modification:	22 avr. 2025 20:47
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/11880

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