Navigating Amaryllidaceae alkaloids: Bridging gaps and charting biosynthetic territories

Liyanage, N. S., Awwad, F., Gonçalves Dos Santos, K. C., Jayawardena, T. U., Merindol, N. et Desgagné-Penix, I. (2024). Navigating Amaryllidaceae alkaloids: Bridging gaps and charting biosynthetic territories. Journal of Experimental Botany, 76 (1). pp. 16-34. ISSN 0022-0957 1460-2431 DOI 10.1093/jxb/erae187

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Abstract

Amaryllidaceae alkaloid (AA) biosynthesis has garnered significant attention in recent years, particularly with the commercialization of galanthamine as a treatment for the symptoms of Alzheimer’s disease. A significant amount of research work over the last eight decades has focused on the understanding of AA biosynthesis, starting from early radiolabelling studies to recent multi-omics analysis with modern biotechnological advancements. Those studies enabled the identification of hundreds of metabolites, the characterization of biochemical pathways, and an understanding of the environmental stimuli and of the molecular regulation of these pharmaceutically and agriculturally important metabolites. Despite numerous studies, there remain significant gaps in understanding the biosynthesis of AAs in Amaryllidaceae plants. As such, further research is needed to fully elucidate the metabolic pathways and facilitate their production. This review aims to provide a comprehensive summary of the current state of knowledge on AA biosynthesis, from elicitation of expression of transcription factors in the cell nucleus to alkaloid transport in the apoplast, and to highlight the challenges that need to be overcome for further advancement.

Type de document:	Article
Mots-clés libres:	Amaryllidoideae Amaryllidaceae alkaloids Biosynthesis galanthamine In vitro culture Isoquinoline alkaloids Multi-omic database Norbelladine Omics Specialized metabolites
Date de dépôt:	22 avr. 2025 19:35
Dernière modification:	22 avr. 2025 19:35
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/11867

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