Unveiling Amaryllidaceae alkaloids: From biosynthesis to antiviral potential - a review

Jayawardena, T. U., Merindol, N., Liyanage, N. S. et Desgagné-Penix, I. (2024). Unveiling Amaryllidaceae alkaloids: From biosynthesis to antiviral potential - a review. Natural Product Reports, 41 (5). pp. 721-747. ISSN 0265-0568 1460-4752 DOI 10.1039/D3NP00044C

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Résumé

Abstract

Covering: 2017 to 2023 (now)
Amaryllidaceae alkaloids (AAs) are a unique class of specialized metabolites containing heterocyclic nitrogen bridging that play a distinct role in higher plants. Irrespective of their diverse structures, most AAs are biosynthesized via intramolecular oxidative coupling. The complex organization of biosynthetic pathways is constantly enlightened by new insights owing to the advancement of natural product chemistry, synthetic organic chemistry, biochemistry, systems and synthetic biology tools and applications. These promote novel compound identification, trace-level metabolite quantification, synthesis, and characterization of enzymes engaged in AA catalysis, enabling the recognition of biosynthetic pathways. A complete understanding of the pathway benefits biotechnological applications in the long run. This review emphasizes the structural diversity of the AA specialized metabolites involved in biogenesis although the process is not entirely defined yet. Moreover, this work underscores the pivotal role of synthetic and enantioselective studies in justifying biosynthetic conclusions. Their prospective candidacy as lead constituents for antiviral drug discovery has also been established. However, a complete understanding of the pathway requires further interdisciplinary efforts in which antiviral studies address the structure-activity relationship. This review presents current knowledge on the topic.

Type de document:	Article
Mots-clés libres:	Amaryllidaceae alkaloids Antiviral agents Biosynthetic pathways Molecular structure Structure-activity relationship Amaryllidaceae alkaloid Antivirus agent Biosynthesis Chemical structure Chemistry Metabolism Structure activity relation
Date de dépôt:	22 avr. 2025 18:13
Dernière modification:	22 avr. 2025 18:13
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/11859

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