Prognostic factors and treatment effect modifiers for physical health, opioid prescription, and health care utilization in patients with musculoskeletal disorders in primary care: Exploratory secondary analysis of the STEMS randomized trial of direct access to physical therapist–led care

Zouch, J., Bhimani, N., Bussières, A., Ferreira, M., Foster, N. E. et Ferreira, P. (2024). Prognostic factors and treatment effect modifiers for physical health, opioid prescription, and health care utilization in patients with musculoskeletal disorders in primary care: Exploratory secondary analysis of the STEMS randomized trial of direct access to physical therapist–led care. Physical Therapy & Rehabilitation Journal, 104 (8). Article pzae066. ISSN 0031-9023 1538-6724 DOI 10.1093/ptj/pzae066

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Résumé

Abstract

Objective
The aims of the study were to identify prognostic factors associated with health care outcomes in patients with musculoskeletal (MSK) conditions in primary care and to determine whether characteristics associated with choice of care modify treatment effects of a direct-access physical therapist–led pathway in addition to general practitioner (GP)–led care compared to GP-led care alone.

Methods
A secondary analysis of a 2-parallel-arm, cluster randomized controlled trial involving general practices in the United Kingdom was conducted. Practices were randomized to continue offering GP-led care or to also offer a direct-access physical therapist–led pathway. Data from adults with MSK conditions who completed the 6-month follow-up questionnaire were analyzed. Outcomes included physical health, opioid prescription, and self-reported health care utilization over 6 months. Treatment effect modifiers were selected a priori from associations in observational studies. Multivariable regression models identified potential prognostic factors, and interaction analysis tested for potential treatment effect modifiers.

Results
Analysis of 767 participants indicated that baseline pain self-efficacy, pain severity, and having low back pain statistically predicted outcomes at 6 months. Higher pain self-efficacy scores at baseline were associated with improved physical health scores, reduced opioid prescription, and less health care utilization. Higher bodily pain at baseline and having low back pain were associated with worse physical health scores and increased opioid prescription. Main interaction analyses did not reveal that patients’ age, level of education, duration of symptoms, or MSK presentation influenced response to treatment, but visual trends suggested those in the older age group proceeded to fewer opioid prescriptions and utilized less health care when offered direct access to physical therapy.

Conclusions
Patients with MSK conditions with lower levels of pain self-efficacy, higher pain severity, and presenting with low back pain have less favorable clinical and health care outcomes in primary care. Prespecified characteristics did not modify the treatment effect of the offer of a direct-access physical therapist–led pathway compared to GP-led care.

Impact
Patients with MSK conditions receiving primary care in the form of direct-access physical therapist–led or GP-led care who have lower levels of self-efficacy, higher pain severity, and low back pain are likely to have a less favorable prognosis. Age and duration of symptoms should be explored as potential patient characteristics that modify the treatment response to a direct-access physical therapist–led model of care.

Type de document:	Article
Mots-clés libres:	Back Pain Effect Modifiers Musculoskeletal Pain Primary Health Care Prognosis
Date de dépôt:	04 nov. 2024 14:53
Dernière modification:	04 nov. 2024 14:53
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/11602

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