Isoflurane anesthesia does not affect spinal cord neurovascular coupling: evidence from decerebrated rats


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Paquette, T., Leblond, H. et Piché, M. (2019). Isoflurane anesthesia does not affect spinal cord neurovascular coupling: evidence from decerebrated rats. Journal of Physiological Sciences, 69 (1). pp. 13-21. ISSN 1880-6546 DOI 10.1007/s12576-018-0607-7

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Neurological examination remains the primary clinical investigation in patients with spinal cord injury. However, neuroimaging methods such as functional magnetic resonance imaging (fMRI) are promising tools for following functional changes in the course of injury, disease and rehabilitation. However, the relationship between neuronal activity and blood flow in the spinal cord on which fMRI relies has been largely overlooked. The objective of this study was to examine neurovascular coupling in the spinal cord of decerebrated rats during electrical stimulation of the sciatic nerve with and without isoflurane anesthesia (1.2%). Local field potentials (LFP) and spinal cord blood flow (SCBF) were recorded simultaneously in the lumbosacral enlargement. Isoflurane did not significantly alter LFP (p = 0.53) and SCBF (p = 0.57) amplitude. Accordingly, neurovascular coupling remained comparable with or without isoflurane anesthesia (p = 0.39). These results support the use of isoflurane in rodents to investigate nociceptive functions of the spinal cord using fMRI. © 2018, The Physiological Society of Japan and Springer Japan KK, part of Springer Nature.

Type de document: Article
Mots-clés libres: Blood flow Local field potential Neurovascular coupling Nociception Pain Spinal cord Inhalation anesthetic agent Isoflurane Action potential Animal Arterial pressure Drug effect Male Nerve cell Rat Vascularization Wistar rat Action potentials Anesthetics, inhalation Animals Neurons Rats Rats, Wistar Regional blood flow
Date de dépôt: 26 avr. 2021 19:54
Dernière modification: 01 mars 2023 20:43
Version du document déposé: Version officielle de l'éditeur

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