Integration of bilateral nociceptive inputs tunes spinal and cerebral responses


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Rustamov, N., Northon, S., Tessier, J., Leblond, H. et Piché, M. (2019). Integration of bilateral nociceptive inputs tunes spinal and cerebral responses. Scientific Reports, 9 (1). ISSN 2045-2322 DOI 10.1038/s41598-019-43567-y

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Together with the nociceptive system, pain protects the body from tissue damage. For instance, when the RIII-reflex is evoked by sural nerve stimulation, nociceptive inputs activate flexor muscles and inhibit extensor muscles of the affected lower limb while producing the opposite effects on the contralateral muscles. But how do the spinal cord and brain integrate concurrent sensorimotor information originating from both limbs? This is critical for evoking coordinated responses to nociceptive stimuli, but has been overlooked. Here we show that the spinal cord integrates spinal inhibitory and descending facilitatory inputs during concurrent bilateral foot stimulation, resulting in facilitation of the RIII-reflex and bilateral flexion. In these conditions, high-gamma oscillation power was also increased in the dorsolateral prefrontal, anterior cingulate and sensorimotor cortex, in accordance with the involvement of these regions in cognitive, motor and pain regulation. We propose that the brain and spinal cord can fine-tune nociceptive and pain responses when nociceptive inputs arise from both lower limbs concurrently, in order to allow adaptable behavioural responses. © 2019, The Author(s).

Type de document: Article
Mots-clés libres: Adult Electrostimulation Evoked response Female Human Lower limb Male Middle aged Pain Pathophysiology Sensorimotor cortex Spinal cord Young adult Electric stimulation Evoked potentials Humans Lower extremity
Date de dépôt: 26 avr. 2021 19:10
Dernière modification: 01 mars 2023 20:54
Version du document déposé: Version officielle de l'éditeur

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