Nucleoporin MOS7/Nup88 contributes to plant immunity and nuclear accumulation of defense regulators


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Wiermer, M., Germain, H., Cheng, Y. T., García, A. V., Parker, J. E. et Li, X. (2010). Nucleoporin MOS7/Nup88 contributes to plant immunity and nuclear accumulation of defense regulators. Nucleus, 1 (4). pp. 332-336. ISSN 1949-1034 1949-1042 DOI 10.4161/nucl.1.4.12109

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Controlled nucleocytoplasmic trafficking is an important feature for fine-tuning signaling pathways in eukaryotic organisms. Nuclear pore complexes (NPCs) composed of nucleoporin proteins (Nups) are essential for the exchange of macromolecules across the nuclear envelope. A recent genetic screen in our laboratory identified a partial loss-of-function mutation in Arabidopsis MOS7/Nup88 that causes defects in basal immunity, Resistance (R) protein-mediated defense and systemic acquired resistance. In Drosophila and mammalian cells, exportin-mediated nuclear export of activated Rel/ NFκB transcription factors is enhanced in nup88 mutants resulting in immune response failure. Consistent with Nup88 promoting nuclear retention of NFκB, our functional analyses revealed that MOS7/Nup88 is required for appropriate nuclear accumulation of the autoactivated R protein snc1, as well as the key immune regulators EDS1 and NPR1. These results suggest that controlling the nuclear concentrations of specific immune regulators is fundamental for defining defense outputs. © 2010 Landes Bioscience.

Type de document: Article
Date de dépôt: 23 oct. 2019 13:15
Dernière modification: 23 oct. 2019 13:15
Version du document déposé: Version officielle de l'éditeur

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