A quick test to objectify smell and taste dysfunction at home: A proof of concept for the validation of the chemosensory perception test


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Levesque-Boissonneault, C., Bussière, N., Roy-Côté, F., Cloutier, F., Caty, M.-È. et Frasnelli, J. (2023). A quick test to objectify smell and taste dysfunction at home: A proof of concept for the validation of the chemosensory perception test. Chemical Senses, 48 . Article bjad033. ISSN 0379-864X 1464-3553 DOI 10.1093/chemse/bjad033

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Recent studies have shown the efficacy of a home test for the self-evaluation of olfactory and gustatory functions in quarantined coronavirus disease-2019 (COVID-19) patients. However, testing was often limited to COVID-19 participants, and the accuracy of home test kits was rarely compared to standardized testing. This study aims at providing proof of concept for the validation of the new Chemosensory Perception Test (CPT) developed to remotely assess orthonasal olfactory, retronasal olfactory, and gustatory functions in various populations using common North American household items. In the 2 experiments, a total of 121 participants irrespective of having olfactory and/or gustatory complaints from various causes (COVID-19, sinunasal, post-viral, idiopathic) were tested first, with one or many of the following tests: (i) a brief chemosensory questionnaire, (ii) an olfactory test—Sniffin’ Sticks Test (SST) or University of Pennsylvania Smell Identification Test (UPSIT), and/or (iii) a gustatory test—Brief Waterless Empirical Taste Test (B-WETT). We then applied the CPT which yielded 3 different subscores, namely orthonasal, retronasal, and gustatory CPT scores. The orthonasal CPT score was significantly correlated with SST (ρ = 0.837, P < 0.001) and UPSIT (ρ = 0.364, P < 0.001) scores, and exhibited an excellent accuracy to identify olfactory dysfunction (OD) as compared to SST (area under the curve [AUC]: 0.923 [95% confidence interval {CI}, 0.822–1.000], P < 0.001). The retronasal CPT score but not the gustatory CPT score allowed to distinguish between participants with or without subjective gustatory complaint (AUC: 0.818 [95% CI, 0.726–0.909], P < 0.001). The CPT has the ability to identify OD and to quantify subjective gustatory complaints.

Type de document: Article
Mots-clés libres: Chemosensory testing COVID-19 Pandemic Remote testing Home test Self-assessment
Date de dépôt: 29 janv. 2024 13:18
Dernière modification: 29 janv. 2024 13:18
Version du document déposé: Post-print (version corrigée et acceptée)
URI: https://depot-e.uqtr.ca/id/eprint/11091

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