Volumetry of olfactory structures in mild cognitive impairment and alzheimer’s disease: A systematic review and a meta-analysis

Jobin, B., Boller, B. et Frasnelli, J. (2021). Volumetry of olfactory structures in mild cognitive impairment and alzheimer’s disease: A systematic review and a meta-analysis. Brain Sciences, 11 (8). Article 1010. ISSN 2076-3425 DOI 10.3390/brainsci11081010

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Résumé

Abtract :
Olfactory decline is an early symptom of Alzheimer’s disease (AD) and is a predictor of conversion from mild cognitive impairment (MCI) to AD. Olfactory decline could reflect AD-related atrophy of structures related to the sense of smell. The aim of this study was to verify whether the presence of a clinical diagnosis of AD or MCI is associated with a volumetric decrease in the olfactory bulbs (OB) and the primary olfactory cortex (POC). We conducted two systematic reviews, one for each region and a meta-analysis. We collected articles from PsychNet, PubMed, Ebsco, and ProQuest databases. Results showed large and heterogeneous effects indicating smaller OB volumes in patients with AD (k = 6, g = −1.21, 95% CI [−2.19, −0.44]) and in patients with MCI compared to controls. There is also a trend for smaller POC in patients with AD or MCI compared to controls. Neuroanatomical structures involved in olfactory processing are smaller in AD and these volumetric reductions could be measured as early as the MCI stage.

Type de document:	Article
Mots-clés libres:	Alzheimer’s disease MCI Meta-analysis MRI Olfactory bulb Primary olfactory cortex
Date de dépôt:	11 juill. 2023 13:32
Dernière modification:	11 juill. 2023 13:32
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/10719

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