Pre-frail older adults show improved cognition with StayFitLonger computerized home–based training: A randomized controlled trial


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Belleville, S., Cuesta, M., Bieler-Aeschlimann, M., Giacomino, K., Widmer, A., Mittaz Hager, A. G., Perez-Marcos, D., Cardin, S., Boller, B., Bier, N., Aubertin-Leheudre, M., Bherer, L., Berryman, N., Agrigoroaei, S. et Demonet, J. F. (2023). Pre-frail older adults show improved cognition with StayFitLonger computerized home–based training: A randomized controlled trial. GeroScience, 45 (2). pp. 811-822. ISSN 2509-2715 2509-2723 DOI 10.1007/s11357-022-00674-5

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Multidomain interventions have shown tremendous potential for improving cognition in older adults. It is unclear if multidomain interventions can be delivered remotely and whether remote intervention is beneficial for older adults who are vulnerable or at risk of cognitive decline. In a 26-week multi-site, home-based, double-blind, randomized controlled trial, 120 cognitively healthy older adults (75 robust, 45 pre-frail; age range = 60–94) recruited from Switzerland, Canada, and Belgium were randomized to receive either the StayFitLonger (SFL) computerized multidomain training program or an active control intervention. Delivered on tablets, the SFL intervention combined adapted physical exercises (strength, balance, and mobility), cognitive training (divided attention, problem solving, and memory), opportunities for social and contributive interactions, and psychoeducation. The active control intervention provided basic mobilization exercises and access to video games. Cognitive outcomes were global cognition (Z-scores of attention, verbal fluency, and episodic memory for nondemented older adults; ZAVEN), memory, executive function, and processing speed. Linear mixed model analyses indicated improved performance on the ZAVEN global cognition score in the SFL group but not in the active control group. Stratified analyses by frailty status revealed improved ZAVEN global cognition and processing speed scores following SFL in the pre-frail group but not in the robust group. Overall, the study indicates that a computerized program providing a multidomain intervention at home can improve cognition in older adults. Importantly, pre-frail individuals, who are at higher risk of cognitive decline, seem to benefit more from the intervention. Trial registration:, NCT037519 Registered on January 22, 2020—Retrospectively registered,

Type de document: Article
Mots-clés libres: Cognitive prevention Cognitive training Frailty Home-based computerized training Physical training Adult Aged Article Automation Clinical effectiveness Clinical outcome Cognition Cognitive defect Controlled study Double blind procedure Female Home care Human Human experiment Male Middle aged Multicenter study Normal human Prospective study Randomized controlled trial Software Training Exercise Frail elderly Kinesiotherapy Psychology Very elderly Aged, 80 and over Cognitive Dysfunction Exercise Therapy Humans
Date de dépôt: 11 juill. 2023 13:01
Dernière modification: 22 oct. 2023 04:00
Version du document déposé: Version officielle de l'éditeur

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