Evidence of a relation between hippocampal volume, white matter hyperintensities, and cognition in subjective cognitive decline and mild cognitive impairment

Caillaud, M., Hudon, C., Boller, B., Brambati, S., Duchesne, S., Lorrain, D., Gagnon, J. F., Maltezos, S., Mellah, S., Phillips, N., Consortium for the Early Identification of Alzheimer's Disease-Q et Belleville, S. (2020). Evidence of a relation between hippocampal volume, white matter hyperintensities, and cognition in subjective cognitive decline and mild cognitive impairment. Journals of Gerontology - Series B Psychological Sciences and Social Sciences, 75 (7). pp. 1382-1392. ISSN 1079-5014 1758-5368 DOI 10.1093/geronb/gbz120

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Résumé

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Objective:
The concepts of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) have been proposed to identify individuals in the early stages of Alzheimer's disease (AD), or other neurodegenerative diseases. One approach to validate these concepts is to investigate the relationship between pathological brain markers and cognition in those individuals.

Method:
We included 126 participants from the Consortium for the Early Identification of Alzheimer's disease-Quebec (CIMA-Q) cohort (67 SCD, 29 MCI, and 30 cognitively healthy controls [CH]). All participants underwent a complete cognitive assessment and structural magnetic resonance imaging. Group comparisons were done using cognitive data, and then correlated with hippocampal volumes and white matter hyperintensities (WMHs).

Results:
Significant differences were found between participants with MCI and CH on episodic and executive tasks, but no differences were found when comparing SCD and CH. Scores on episodic memory tests correlated with hippocampal volumes in both MCI and SCD, whereas performance on executive tests correlated with WMH in all of our groups.

Discussion:
As expected, the SCD group was shown to be cognitively healthy on tasks where MCI participants showed impairment. However, SCD's hippocampal volume related to episodic memory performances, and WMH to executive functions. Thus, SCD represents a valid research concept and should be used, alongside MCI, to better understand the preclinical/ prodromal phase of AD.

Type de document:	Article
Mots-clés libres:	Alzheimer's disease Biomarkers Neuroimaging Neuropsychology Aged Anatomy and histology Clinical trial Cognition Cognitive defect Dementia assessment Diagnostic imaging Episodic memory Executive function Female Hippocampus Human Longitudinal study Male Multicenter study Nuclear magnetic resonance imaging Organ size Pathology Psychology Self evaluation White matter Cognitive Dysfunction Diagnostic Self Evaluation Humans Longitudinal Studies Magnetic Resonance Imaging Memory, Episodic Mental Status and Dementia Tests
Date de dépôt:	11 juill. 2023 12:49
Dernière modification:	11 juill. 2023 12:49
Version du document déposé:	Version officielle de l'éditeur
URI:	https://depot-e.uqtr.ca/id/eprint/10712

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