Mitochondrial dynamics and mitophagy in skeletal muscle health and aging


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Leduc-Gaudet, J. P., Hussain, S. N. A., Barreiro, E. et Gouspillou, G. (2021). Mitochondrial dynamics and mitophagy in skeletal muscle health and aging. International Journal of Molecular Sciences, 22 (15). Article 22158179. ISSN 1661-6596 DOI 10.3390/ijms22158179

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The maintenance of mitochondrial integrity is critical for muscle health. Mitochondria, indeed, play vital roles in a wide range of cellular processes, including energy supply, Ca2+ homeostasis, retrograde signaling, cell death, and many others. All mitochondria-containing cells, including skeletal muscle cells, dispose of several pathways to maintain mitochondrial health, including mitochondrial biogenesis, mitochondrial-derived vesicles, mitochondrial dynamics (fusion and fission process shaping mitochondrial morphology), and mitophagy—the process in charge of the removal of mitochondria though autophagy. The loss of skeletal muscle mass (atrophy) is a major health problem worldwide, especially in older people. Currently, there is no treatment to counteract the progressive decline in skeletal muscle mass and strength that occurs with aging, a process termed sarcopenia. There is increasing data, including our own, suggesting that accumulation of dysfunctional mitochondria contributes to the development of sarcopenia. Impairments in mitochondrial dynamics and mitophagy were recently proposed to contribute to sarcopenia. This review summarizes the current state of knowledge on the role played by mitochondrial dynamics and mitophagy in skeletal muscle health and in the development of sarcopenia. We also highlight recent studies showing that enhancing mitophagy in skeletal muscle is a promising therapeutic target to prevent or even treat skeletal muscle dysfunction in the elderly.

Type de document: Article
Mots-clés libres: Aging Autophagy Mitochondrial dynamics Mitophagy Sarcopenia Skeletal muscle Mitofusin 2 Autophagosome Autophagy (cellular) Health Human Knowledge Mitochondrial membrane potential Muscle function Muscle mass muscle strength Nonhuman Pathogenesis Review Skeletal muscle cell Animal Growth, development and aging Metabolism Muscle mitochondrion Animals Humans Mitochondria, Muscle Muscle, Skeletal
Date de dépôt: 10 juill. 2023 18:10
Dernière modification: 10 juill. 2023 18:10
Version du document déposé: Version officielle de l'éditeur

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