Contribution of astrocytes to neurovascular coupling in the spinal cord of the rat


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Paquette, T., Piché, M. et Leblond, H. (2021). Contribution of astrocytes to neurovascular coupling in the spinal cord of the rat. Journal of Physiological Sciences, 71 (1). ISSN 1880-6546 DOI 10.1186/s12576-021-00800-6

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Functional magnetic resonance imaging (fMRI) of the spinal cord relies on the integrity of neurovascular coupling (NVC) to infer neuronal activity from hemodynamic changes. Astrocytes are a key component of cerebral NVC, but their role in spinal NVC is unclear. The objective of this study was to examine whether inhibition of astrocyte metabolism by fluorocitrate alters spinal NVC. In 14 rats, local field potential (LFP) and spinal cord blood flow (SCBF) were recorded simultaneously in the lumbosacral enlargement during noxious stimulation of the sciatic nerve before and after a local administration of fluorocitrate (N = 7) or saline (N = 7). Fluorocitrate significantly reduced SCBF responses (p < 0.001) but not LFP amplitude (p = 0.22) compared with saline. Accordingly, NVC was altered by fluorocitrate compared with saline (p < 0.01). These results support the role of astrocytes in spinal NVC and have implications for spinal cord imaging with fMRI for conditions in which astrocyte metabolism may be altered. © 2021, The Author(s).

Type de document: Article
Mots-clés libres: Astrocyte Blood flow Fluorocitrate Local field potential Neurovascular coupling Spinal cord
Date de dépôt: 14 mars 2022 18:02
Dernière modification: 14 mars 2022 18:02
Version du document déposé: Version officielle de l'éditeur

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