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0 Tc 1.092 0 Td
(, )Tj
0.235 0.231 0.235 scn
0.0164 Tc 0.93 0 Td
(Aiken )Tj
0 Tc 3.246 0 Td
(C)Tj
0.333 0.333 0.341 scn
0.721 0 Td
(. )Tj
0.235 0.231 0.235 scn
0.0081 Tc 0.912 0 Td
(Proteasomal )Tj
0.0093 Tc 5.751 0 Td
(degradation )Tj
0.05 Tc 12.5203 0 0 11.8 386.04 318.49 Tm
(of )Tj
0.031 Tc 11.8 0 0 11.8 404.3 318.49 Tm
(TRIM5a )Tj
0.0045 Tc 4.311 0 Td
(during )Tj
0 Tc 3.364 0 Td
(retrovirus )Tj
0.0049 Tc -30.163 -1.18 Td
(restriction. )Tj
0.0034 Tc 4.696 0 Td
(PLoS )Tj
0.011 Tc 2.548 0 Td
(pathog )Tj
0.0184 Tc 3.084 0 Td
(2008;4\(5\):el000074. )Tj
-0.035 Tc 11.7438 0 0 11.8 111.67 278.4 Tm
(147. )Tj
0.0191 Tc 11.8 0 0 11.8 139.15 278.4 Tm
(Mizushima )Tj
0 Tc 4.849 0 Td
(N)Tj
0.333 0.333 0.341 scn
0.793 0 Td
(, )Tj
0.235 0.231 0.235 scn
0.0055 Tc 0.502 0 Td
(Yoshimori )Tj
0 Tc 4.611 0 Td
(T)Tj
0.333 0.333 0.341 scn
0.643 0 Td
(, )Tj
0.235 0.231 0.235 scn
0.002 Tc 0.494 0 Td
(Ohsumi )Tj
-0.0349 Tc 11.1 0 0 11.1 320.61 278.4 Tm
(Y. )Tj
0.0046 Tc 11.8 0 0 11.8 334.94 278.4 Tm
(The )Tj
0.0045 Tc 1.817 0 Td
(role )Tj
0.05 Tc 12.7985 0 0 11.8 378.12 278.4 Tm
(of )Tj
0.0059 Tc 11.8 0 0 11.8 391.18 278.4 Tm
(Atg )Tj
0.0121 Tc 1.753 0 Td
(proteins )Tj
0.012 Tc 3.59 0 Td
(in )Tj
0.0037 Tc 1.036 0 Td
(autophagosome )Tj
0.0001 Tc -27.743 -1.158 Td
(formation. )Tj
0.0067 Tc 4.586 0 Td
(Annual )Tj
0.0097 Tc 3.295 0 Td
(review )Tj
0.05 Tc 12.7985 0 0 11.8 267.96 264.73 Tm
(of )Tj
-0.0055 Tc 11.8 0 0 11.8 281.16 264.73 Tm
(cell )Tj
-0.0041 Tc 1.729 0 Td
(and )Tj
0.0074 Tc 1.73 0 Td
(developmental )Tj
0.0079 Tc 6.315 0 Td
(biology )Tj
-0.0299 Tc (2011 )Tj
0.333 0.333 0.341 scn
0 Tc 5.45 0 Td
(;)Tj
0.235 0.231 0.235 scn
-0.029 Tc 0.258 0 Td
(27: )Tj
-0.0113 Tc 1.395 0 Td
(107-32)Tj
0.333 0.333 0.341 scn
0 Tc 2.82 0 Td
(. )Tj
0.235 0.231 0.235 scn
-0.0307 Tc -34.061 -2.217 Td
(148. )Tj
0.0098 Tc 2.329 0 Td
(Kwarteng )Tj
0 Tc 4.294 0 Td
(A)Tj
0.333 0.333 0.341 scn
0.738 0 Td
(, )Tj
0.235 0.231 0.235 scn
0.0074 Tc 0.462 0 Td
(Ahuno )Tj
0.0075 Tc 3.034 0 Td
(ST)Tj
0.333 0.333 0.341 scn
0 Tc 1.203 0 Td
(, )Tj
0.235 0.231 0.235 scn
0.0051 Tc 0.479 0 Td
(Kwak)Tj
0.333 0.333 0.341 scn
0 Tc 2.443 0 Td
(y)Tj
0.235 0.231 0.235 scn
0.0027 Tc 0.499 0 Td
(e-Nuako )Tj
-0.035 Tc 11.1937 0 0 11.8 338.53 238.57 Tm
(G. )Tj
-0.0056 Tc 11.8 0 0 11.8 352.7 238.57 Tm
(The )Tj
0.0082 Tc 1.796 0 Td
(therapeutic )Tj
0.0054 Tc 4.814 0 Td
(landscape )Tj
0.05 Tc 11.9328 0 0 11.8 480.6 238.57 Tm
(ofHIV-l )Tj
0.0029 Tc 11.8 0 0 11.8 526.78 238.57 Tm
(via )Tj
0.0049 Tc -32.834 -1.18 Td
(genome )Tj
0.0008 Tc 3.496 0 Td
(editing. )Tj
-0.0028 Tc 3.385 0 Td
(AIDS )Tj
0.0092 Tc 2.661 0 Td
(Research )Tj
-0.0041 Tc 4.002 0 Td
(and )Tj
0.0072 Tc 1.731 0 Td
(Therapy )Tj
0.0069 Tc 3.664 0 Td
(2017;14\(1\):32. )Tj
-0.0329 Tc -21.283 -2.217 Td
(149)Tj
0.333 0.333 0.341 scn
0 Tc 1.478 0 Td
(. )Tj
0.235 0.231 0.235 scn
0.0143 Tc 0.851 0 Td
(Maeder )Tj
0.0166 Tc 3.376 0 Td
(ML)Tj
0.333 0.333 0.341 scn
0 Tc 1.575 0 Td
(, )Tj
0.235 0.231 0.235 scn
0.0094 Tc 0.494 0 Td
(Gersbach )Tj
-0.0252 Tc 4.129 0 Td
(CA. )Tj
0.0087 Tc 1.912 0 Td
(Genome-editing )Tj
0.009 Tc 6.842 0 Td
(technologies )Tj
-0.0028 Tc 5.442 0 Td
(for )Tj
0 Tc 1.467 0 Td
(gene )Tj
-0.0041 Tc 2.154 0 Td
(and )Tj
-0.0123 Tc 1.729 0 Td
(cell )Tj
-0.0006 Tc 1.675 0 Td
(therapy)Tj
0.333 0.333 0.341 scn
0 Tc 3.073 0 Td
(. )Tj
0.235 0.231 0.235 scn
0.0119 Tc -33.868 -1.159 Td
(Molecular )Tj
0.014 Tc 4.47 0 Td
(Therapy )Tj
0.0063 Tc 3.704 0 Td
(2016;24\(3\):430-46. )Tj
-0.0307 Tc -10.525 -2.177 Td
(150. )Tj
0.0101 Tc 2.328 0 Td
(Holkers )Tj
0 Tc 3.926 0 Td
(M)Tj
0.333 0.333 0.341 scn
0.944 0 Td
(, )Tj
0.235 0.231 0.235 scn
0.0068 Tc 0.907 0 Td
(Maggio )Tj
0 Tc 3.881 0 Td
(l)Tj
0.333 0.333 0.341 scn
0.338 0 Td
(, )Tj
0.235 0.231 0.235 scn
0.0042 Tc 0.925 0 Td
(Liu )Tj
0 Tc 2.075 0 Td
(J)Tj
0.333 0.333 0.341 scn
0.437 0 Td
(, )Tj
0.235 0.231 0.235 scn
0.0078 Tc 0.885 0 Td
(Janssen )Tj
-0.0074 Tc 3.783 0 Td
(JM, )Tj
0.0048 Tc 2.219 0 Td
(Miselli )Tj
0 Tc 3.6 0 Td
(F)Tj
0.333 0.333 0.341 scn
0.578 0 Td
(, )Tj
0.235 0.231 0.235 scn
0.005 Tc 0.907 0 Td
(Mussolino )Tj
0 Tc 4.977 0 Td
(C )Tj
/T1_1 1 Tf
0.003 Tc 11.5 0 0 11.5 513.26 159.13 Tm
(et )Tj
-0.035 Tc 10.631 0 0 11.1 529.37 159.13 Tm
(al. )Tj
/T1_0 1 Tf
0.0056 Tc 11.8 0 0 11.8 138.9 145.21 Tm
(DifferentiaI )Tj
0.0087 Tc 5.163 0 Td
(integrity )Tj
0.05 Tc 12.5203 0 0 11.8 244.92 145.21 Tm
(of )Tj
0.0023 Tc 11.8 0 0 11.8 259.1 145.21 Tm
(TALE )Tj
0.0062 Tc 2.936 0 Td
(nuclease )Tj
-0.0007 Tc 3.878 0 Td
(genes )Tj
0.0051 Tc 2.662 0 Td
[(following )-143(adenoviral )]TJ
-0.0143 Tc 9.011 0 Td
(and )Tj
-0.0033 Tc 1.792 0 Td
(lentiviral )Tj
0.0144 Tc -30.461 -1.159 Td
(vector )Tj
0.0067 Tc 2.841 0 Td
(gene )Tj
0.0119 Tc 2.182 0 Td
(transfer )Tj
-0.0041 Tc 3.431 0 Td
(into )Tj
0.0125 Tc 1.858 0 Td
(human )Tj
-0.0091 Tc 3.042 0 Td
(cells. )Tj
0.0079 Tc 2.374 0 Td
(Nucleic )Tj
0.0033 Tc 3.443 0 Td
(acids )Tj
0.01 Tc 2.368 0 Td
(research )Tj
-0.0095 Tc 3.677 0 Td
(2013)Tj
0.333 0.333 0.341 scn
0 Tc 2.101 0 Td
(;)Tj
0.235 0.231 0.235 scn
0.0017 Tc 0.24 0 Td
(41\(5\):e63-e63. )Tj
ET
q
/CS0 cs 0.159 0.159 0.159 scn
433.9199982 0 0 629.7599945 111.3600006 126.4559937 cm
/Im0 Do
Q
endstream
endobj
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