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(Wang, )Tj
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(Y., )Tj
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(Balaji, )Tj
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(V., )Tj
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(Kaniyappan, )Tj
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(S., )Tj
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(Kruger, )Tj
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(L., )Tj
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(Irsen, )Tj
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(S., )Tj
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(Tepper, )Tj
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(K, )Tj
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(Chandupatla, )Tj
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(R., )Tj
0.05 Tc 12.4372 0 0 12.4 258.9 697.68 Tm
(Maetzler, )Tj
0.027 Tc 12.4 0 0 12.4 321.32 697.68 Tm
(W., )Tj
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(Schneider, )Tj
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(A., )Tj
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(Mandelkow, )Tj
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(E., )Tj
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(Mandelkow, )Tj
0.041 Tc 12.4 0 0 12.4 229.85 683.29 Tm
(E.M., )Tj
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(2017. )Tj
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(The )Tj
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(release )Tj
14.0998 0 0 12.4 419.85 683.29 Tm
(and )Tj
13.3981 0 0 12.4 457.89 683.29 Tm
(trans-synaptic )Tj
13.5033 0 0 12.4 143.73 669.36 Tm
(transmission )Tj
12.7985 0 0 12.4 223.8 669.36 Tm
(of )Tj
13.6385 0 0 12.4 237.72 669.36 Tm
(Tau )Tj
12.598 0 0 12.4 264.45 669.36 Tm
(via )Tj
12.8631 0 0 12.4 285.22 669.36 Tm
(exosomes. )Tj
0.0045 Tc 12.4 0 0 12.4 349.86 669.36 Tm
(Mol )Tj
0.05 Tc 12.7557 0 0 12.4 375.18 669.36 Tm
(Neurodegener. )Tj
0.0494 Tc 12.4 0 0 12.4 464.69 669.36 Tm
(12, )Tj
0.039 Tc 1.724 0 Td
(5. )Tj
0.0162 Tc -29.912 -2.632 Td
(Wei, )Tj
-0.017 Tc 2.865 0 Td
(Y., )Tj
0.05 Tc 13.0877 0 0 12.4 177.54 636.72 Tm
(Han, )Tj
0.0375 Tc 12.4 0 0 12.4 216.59 636.72 Tm
(C., )Tj
0.05 Tc 12.6391 0 0 12.4 243.56 636.72 Tm
(Wang, )Tj
-0.017 Tc 12.4 0 0 12.4 290.85 636.72 Tm
(Y., )Tj
0.05 Tc 12.6293 0 0 12.4 317.24 636.72 Tm
(Wu, )Tj
0.0472 Tc 12.4 0 0 12.4 352.26 636.72 Tm
(B., )Tj
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(Su, )Tj
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(T., )Tj
0.0326 Tc 2.132 0 Td
(Liu, )Tj
-0.0267 Tc 2.674 0 Td
(Y., )Tj
0.0239 Tc 2.146 0 Td
(He, )Tj
0.0085 Tc 2.419 0 Td
(R., )Tj
0.05 Tc 13.1299 0 0 12.4 143.68 622.57 Tm
(2015. )Tj
12.6502 0 0 12.4 193.14 622.57 Tm
(Ribosylation )Tj
12.6902 0 0 12.4 281.25 622.57 Tm
(triggering )Tj
12.5953 0 0 12.4 352.78 622.57 Tm
(Alzheimer's )Tj
12.7879 0 0 12.4 435.96 622.57 Tm
(disease-like )Tj
13.6385 0 0 12.4 519.24 622.57 Tm
(Tau )Tj
13.1631 0 0 12.4 143.74 608.41 Tm
(hyperphosphorylation )Tj
12.7806 0 0 12.4 280.53 608.41 Tm
(via )Tj
12.9984 0 0 12.4 306.35 608.41 Tm
(activation )Tj
12.7985 0 0 12.4 372.6 608.41 Tm
(of )Tj
0.0105 Tc 12.4 0 0 12.4 392.03 608.41 Tm
(CaMKII. )Tj
0.0299 Tc 4.48 0 Td
(Aging )Tj
0.0159 Tc 3.34 0 Td
(Cell. )Tj
0.0397 Tc 2.879 0 Td
(14, )Tj
0.05 Tc 13.141 0 0 12.4 143.86 594.24 Tm
(754-763. )Tj
0.0243 Tc 12.4 0 0 12.4 114.92 561.6 Tm
(Wilcox, )Tj
0.05 Tc 13.557 0 0 12.4 164.34 561.6 Tm
(KC., )Tj
0.0479 Tc 12.4 0 0 12.4 200.09 561.6 Tm
(Lacor, )Tj
0.0291 Tc 3.465 0 Td
(P.N., )Tj
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(Pitt,J., )Tj
0.0253 Tc 12.4 0 0 12.4 330.42 561.6 Tm
(Klein, )Tj
0.0162 Tc 3.234 0 Td
(W.L., )Tj
0.05 Tc 13.0312 0 0 12.4 408.16 561.6 Tm
(2011. )Tj
12.8413 0 0 12.4 447.81 561.6 Tm
(Abeta )Tj
0.0447 Tc 12.4 0 0 12.4 488.04 561.6 Tm
(oligomer\255)Tj
0.05 Tc 13.4384 0 0 12.4 143.41 547.45 Tm
(induced )Tj
13.4701 0 0 12.4 199.25 547.45 Tm
(synapse )Tj
13.1369 0 0 12.4 255.23 547.45 Tm
(degeneration )Tj
13.3194 0 0 12.4 339.49 547.45 Tm
(in )Tj
12.5489 0 0 12.4 359.5 547.45 Tm
(Alzheimer)Tj
0.345 0.349 0.357 scn
0 Tc 12.4 0 0 12.4 417.94 547.45 Tm
(')Tj
0.196 0.188 0.2 scn
0.21 0 Td
(s )Tj
0.05 Tc 12.9842 0 0 12.4 435.24 547.45 Tm
(disease. )Tj
0.0271 Tc 12.4 0 0 12.4 490.43 547.45 Tm
(Cell )Tj
-0.0051 Tc 2.483 0 Td
(Mol )Tj
0.0467 Tc -30.436 -1.142 Td
(Neurobiol. )Tj
0.05 Tc 13.9575 0 0 12.4 207.92 533.29 Tm
(31,939-948. )Tj
12.6293 0 0 12.4 114.92 500.65 Tm
(Wu, )Tj
0.018 Tc 12.4 0 0 12.4 141.82 500.65 Tm
(X.L., )Tj
0.05 Tc 12.9126 0 0 12.4 173.46 500.65 Tm
(Pina-Crespo, )Tj
14.1918 0 0 12.4 251.68 500.65 Tm
(J., )Tj
13.0232 0 0 12.4 270.44 500.65 Tm
(Zhang, )Tj
0.0029 Tc 12.4 0 0 12.4 314.61 500.65 Tm
(Y.W., )Tj
0.05 Tc 13.0528 0 0 12.4 349.78 500.65 Tm
(Chen, )Tj
0.033 Tc 12.4 0 0 12.4 387.58 500.65 Tm
(X.C., )Tj
0.05 Tc 12.5645 0 0 12.4 420.22 500.65 Tm
(Xu, )Tj
0.0253 Tc 12.4 0 0 12.4 444.9 500.65 Tm
(H.X., )Tj
0.05 Tc 13.0312 0 0 12.4 478.24 500.65 Tm
(2017. )Tj
13.0723 0 0 12.4 514.69 500.65 Tm
(Tau\255)Tj
13.2417 0 0 12.4 143.49 486.49 Tm
(mediated )Tj
12.9975 0 0 12.4 200.7 486.49 Tm
(Neurodegeneration )Tj
14.2564 0 0 12.4 314.49 486.49 Tm
(and )Tj
12.9313 0 0 12.4 340.5 486.49 Tm
(Potential )Tj
12.9371 0 0 12.4 395.19 486.49 Tm
(Implications )Tj
13.3194 0 0 12.4 470.53 486.49 Tm
(in )Tj
12.7659 0 0 12.4 485.46 486.49 Tm
(Diagnosis )Tj
14.0998 0 0 12.4 143.37 472.33 Tm
(and )Tj
13.4269 0 0 12.4 172.68 472.33 Tm
(Treatment )Tj
13.0768 0 0 12.4 240.59 472.33 Tm
(of )Tj
12.6407 0 0 12.4 258.22 472.33 Tm
(Alzheimer's )Tj
12.815 0 0 12.4 333.3 472.33 Tm
(Disease. )Tj
13.2085 0 0 12.4 389.38 472.33 Tm
(Chin )Tj
0.0473 Tc 12.4 0 0 12.4 424.98 472.33 Tm
(Med )Tj
0 Tc 2.535 0 Td
(J )Tj
0.0134 Tc 1.232 0 Td
(\(Engl\). )Tj
0.05 Tc 12.5999 0 0 12.4 517.24 472.33 Tm
(130, )Tj
13.2108 0 0 12.4 143.68 458.17 Tm
(2978-2990. )Tj
12.4204 0 0 12.4 114.69 425.52 Tm
(Yester, )Tj
12.8769 0 0 12.4 157.61 425.52 Tm
(J.W., )Tj
12.4079 0 0 12.4 190.93 425.52 Tm
(Tizazu, )Tj
12.4296 0 0 12.4 235.85 425.52 Tm
(E., )Tj
13.3471 0 0 12.4 255.3 425.52 Tm
(Harikumar, )Tj
13.557 0 0 12.4 326.82 425.52 Tm
(KB., )Tj
12.7039 0 0 12.4 358.74 425.52 Tm
(Kordula, )Tj
0.0242 Tc 12.4 0 0 12.4 411.73 425.52 Tm
(T., )Tj
0.05 Tc 13.1299 0 0 12.4 430.24 425.52 Tm
(2011. )Tj
12.9964 0 0 12.4 466.97 425.52 Tm
(Extracellular )Tj
14.0998 0 0 12.4 143.37 411.36 Tm
(and )Tj
13.2277 0 0 12.4 177.73 411.36 Tm
(intracellular )Tj
13.3578 0 0 12.4 261.89 411.36 Tm
(sphingosine-1-phosphate )Tj
0 Tc 12.4 0 0 12.4 422.85 411.36 Tm
(m )Tj
0.05 Tc 13.0146 0 0 12.4 446.27 411.36 Tm
(cancer. )Tj
13.2706 0 0 12.4 500.98 411.36 Tm
(Cancer )Tj
13.249 0 0 12.4 143.46 397.21 Tm
(Metastasis )Tj
0.0005 Tc 12.4 0 0 12.4 209.94 397.21 Tm
(Rev. )Tj
0.05 Tc 13.1597 0 0 12.4 238.4 397.21 Tm
(30, )Tj
13.1733 0 0 12.4 261.18 397.21 Tm
(577-597. )Tj
13.0232 0 0 12.4 114.92 364.8 Tm
(Zhang, )Tj
14.1918 0 0 12.4 160.72 364.8 Tm
(J., )Tj
13.0232 0 0 12.4 180.92 364.8 Tm
(Zhang, )Tj
0.039 Tc 12.4 0 0 12.4 227 364.8 Tm
(Z.G., )Tj
-0.0301 Tc 2.765 0 Td
(Li, )Tj
-0.017 Tc 1.552 0 Td
(Y., )Tj
0.0467 Tc 1.72 0 Td
(Ding, )Tj
0.0209 Tc 2.906 0 Td
(X., )Tj
0.05 Tc 13.1964 0 0 12.4 360.24 364.8 Tm
(Shang, )Tj
0.0112 Tc 12.4 0 0 12.4 405.82 364.8 Tm
(X., )Tj
0.0423 Tc 1.777 0 Td
(Lu, )Tj
0.0075 Tc 1.975 0 Td
(M., )Tj
0.05 Tc 12.5647 0 0 12.4 476.09 364.8 Tm
(Elias, )Tj
0.0479 Tc 12.4 0 0 12.4 513.85 364.8 Tm
(S.B., )Tj
0.05 Tc 12.9755 0 0 12.4 143.38 350.65 Tm
(Chopp, )Tj
-0.0021 Tc 12.4 0 0 12.4 190.5 350.65 Tm
(M., )Tj
0.05 Tc 13.1299 0 0 12.4 213.76 350.65 Tm
(2015. )Tj
12.6196 0 0 12.4 252.18 350.65 Tm
(Fingolimod )Tj
13.7632 0 0 12.4 322.04 350.65 Tm
(treatment )Tj
13.2414 0 0 12.4 384.5 350.65 Tm
(promotes )Tj
12.6362 0 0 12.4 443.54 350.65 Tm
(proliferation )Tj
13.9431 0 0 12.4 519.46 350.65 Tm
(and )Tj
12.7046 0 0 12.4 143.4 336.49 Tm
(differentiation )Tj
13.0768 0 0 12.4 234.59 336.49 Tm
(of )Tj
12.6482 0 0 12.4 254.52 336.49 Tm
(oligodendrocyte )Tj
12.9801 0 0 12.4 355.46 336.49 Tm
(progenitor )Tj
12.5439 0 0 12.4 424.68 336.49 Tm
(cells )Tj
13.3194 0 0 12.4 459.73 336.49 Tm
(in )Tj
12.5435 0 0 12.4 480.45 336.49 Tm
(mice )Tj
12.9896 0 0 12.4 516.22 336.49 Tm
(with )Tj
13.1215 0 0 12.4 143.14 322.08 Tm
(experimental )Tj
13.6852 0 0 12.4 227.38 322.08 Tm
(auto )Tj
13.5468 0 0 12.4 253.81 322.08 Tm
(immune )Tj
12.825 0 0 12.4 310.66 322.08 Tm
(encephalomyelitis. )Tj
12.5066 0 0 12.4 427.97 322.08 Tm
(Neurobiol )Tj
0.0337 Tc 12.4 0 0 12.4 492.42 322.08 Tm
(Dis. )Tj
0.05 Tc 12.8566 0 0 12.4 523.54 322.08 Tm
(76, )Tj
13.12 0 0 12.4 143.34 307.93 Tm
(57-66. )Tj
13.0232 0 0 12.4 114.92 275.29 Tm
(Zhang, )Tj
0.0195 Tc 12.4 0 0 12.4 164.85 275.29 Tm
(Y.H., )Tj
0.05 Tc 13.3209 0 0 12.4 203.94 275.29 Tm
(Fehrenbacher, )Tj
13.341 0 0 12.4 298.24 275.29 Tm
(J.C., )Tj
12.6798 0 0 12.4 335.73 275.29 Tm
(Vasko, )Tj
0.0264 Tc 12.4 0 0 12.4 385.38 275.29 Tm
(M.R., )Tj
0.0094 Tc 3.299 0 Td
(Nicol, )Tj
0.0359 Tc 3.411 0 Td
(G.D., )Tj
0.05 Tc 12.9325 0 0 12.4 508.72 275.29 Tm
(2006. )Tj
13.2984 0 0 12.4 143.28 261.36 Tm
(Sphingosine-1-phosphate )Tj
12.7806 0 0 12.4 303.33 261.36 Tm
(via )Tj
12.9435 0 0 12.4 330.59 261.36 Tm
(activation )Tj
12.7985 0 0 12.4 398.04 261.36 Tm
(of )Tj
0 Tc 12.4 0 0 12.4 418.67 261.36 Tm
(a )Tj
0.05 Tc 12.9024 0 0 12.4 435.71 261.36 Tm
(G-protein-coupled )Tj
12.4309 0 0 12.4 143.26 246.97 Tm
(receptor\(s\) )Tj
13.71 0 0 12.4 215.37 246.97 Tm
(enhances )Tj
13.6607 0 0 12.4 281.73 246.97 Tm
(the )Tj
12.6184 0 0 12.4 311.38 246.97 Tm
(excitability )Tj
12.7985 0 0 12.4 385.8 246.97 Tm
(of )Tj
14.3663 0 0 12.4 407.02 246.97 Tm
(rat )Tj
13.2663 0 0 12.4 434.69 246.97 Tm
(sensory )Tj
13.3344 0 0 12.4 490.3 246.97 Tm
(neurons. )Tj
0 Tc 12.4 0 0 12.4 142.73 232.81 Tm
(J )Tj
0.05 Tc 12.5512 0 0 12.4 154.61 232.81 Tm
(Neurophysiol. )Tj
13.2217 0 0 12.4 238.89 232.81 Tm
(96, )Tj
13.1087 0 0 12.4 262.82 232.81 Tm
(1042-1052. )Tj
12.9056 0 0 12.4 114.92 200.4 Tm
(Zhou, )Tj
14.4365 0 0 12.4 152.56 200.4 Tm
(J., )Tj
13.4561 0 0 12.4 171.94 200.4 Tm
(Gennatas, )Tj
12.4805 0 0 12.4 236.09 200.4 Tm
(E.D., )Tj
12.8041 0 0 12.4 269.7 200.4 Tm
(Kramer, )Tj
13.4448 0 0 12.4 320.56 200.4 Tm
(J.H., )Tj
0.0247 Tc 12.4 0 0 12.4 353.46 200.4 Tm
(Miller, )Tj
0.0263 Tc 3.31 0 Td
(B.L., )Tj
0.043 Tc 2.56 0 Td
(Seeley, )Tj
0.0104 Tc 3.538 0 Td
(W.W., )Tj
0.05 Tc 12.9325 0 0 12.4 508.72 200.4 Tm
(2012. )Tj
12.844 0 0 12.4 143.22 186 Tm
(Predicting )Tj
12.7861 0 0 12.4 212.38 186 Tm
(regional )Tj
13.295 0 0 12.4 269.74 186 Tm
(neurodegeneration )Tj
12.4989 0 0 12.4 390.34 186 Tm
(from )Tj
13.4786 0 0 12.4 427.89 186 Tm
(the )Tj
13.2753 0 0 12.4 457.18 186 Tm
(healthy )Tj
13.4796 0 0 12.4 510.97 186 Tm
(brain )Tj
13.0112 0 0 12.4 143.13 172.09 Tm
(functional )Tj
13.0023 0 0 12.4 206.27 172.09 Tm
(connectome. )Tj
12.7845 0 0 12.4 284.46 172.09 Tm
(Neuron. )Tj
12.8566 0 0 12.4 335.38 172.09 Tm
(73, )Tj
13.1087 0 0 12.4 358.82 172.09 Tm
(1216-1227. )Tj
13.2149 0 0 12.4 114.67 140.17 Tm
(Zhu, )Tj
0.0112 Tc 12.4 0 0 12.4 147.34 140.17 Tm
(X., )Tj
0.05 Tc 13.0262 0 0 12.4 169.38 140.17 Tm
(Rottkamp, )Tj
0.0177 Tc 12.4 0 0 12.4 236.03 140.17 Tm
(C.A., )Tj
0.05 Tc 12.766 0 0 12.4 269.7 140.17 Tm
(Boux, )Tj
0.0333 Tc 12.4 0 0 12.4 309.54 140.17 Tm
(H., )Tj
0.05 Tc 13.1316 0 0 12.4 331.57 140.17 Tm
(Takeda, )Tj
-0.0081 Tc 12.4 0 0 12.4 383.5 140.17 Tm
(A., )Tj
0.05 Tc 12.4092 0 0 12.4 405.06 140.17 Tm
(Perry, )Tj
0.0352 Tc 12.4 0 0 12.4 444.59 140.17 Tm
(G., )Tj
0.05 Tc 13.1256 0 0 12.4 467.28 140.17 Tm
(Smith, )Tj
-0.0021 Tc 12.4 0 0 12.4 511.38 140.17 Tm
(M.A., )Tj
0.05 Tc 13.1299 0 0 12.4 143.2 126 Tm
(2000. )Tj
12.5146 0 0 12.4 180.7 126 Tm
(Activation )Tj
12.7985 0 0 12.4 244.2 126 Tm
(of )Tj
13.4256 0 0 12.4 259.22 126 Tm
(p38 )Tj
13.4519 0 0 12.4 286.05 126 Tm
(kinase )Tj
13.1971 0 0 12.4 329.17 126 Tm
(links )Tj
14.3893 0 0 12.4 362.84 126 Tm
(tau )Tj
13.0467 0 0 12.4 386.9 126 Tm
(phosphorylation, )Tj
0.046 Tc 12.4 0 0 12.4 490.44 126 Tm
(oxidative )Tj
0.05 Tc 13.4658 0 0 12.4 143.33 111.84 Tm
(stress, )Tj
14.0998 0 0 12.4 194.49 111.84 Tm
(and )Tj
0.0364 Tc 12.4 0 0 12.4 229.8 111.84 Tm
(cell )Tj
0.05 Tc 12.7639 0 0 12.4 262.67 111.84 Tm
(cycle-related )Tj
13.198 0 0 12.4 349.54 111.84 Tm
(events )Tj
13.3194 0 0 12.4 399.97 111.84 Tm
(in )Tj
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