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Cortical integration of bilateral nociceptive signals: when more is less

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Northon, Stéphane et Rustamov, Nabi et Piché, Mathieu (2019). Cortical integration of bilateral nociceptive signals: when more is less. Pain, 160 (3). p. 724-733. ISSN 0304-3959 DOI 10.1097/j.pain.0000000000001451

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Résumé

Integration of nociceptive information is essential to produce adapted responses, to promote body integrity and survival. However, how the brain integrates nociceptive inputs from different body areas remains unknown. The aim of this study was to examine the cortical integration of bilateral nociceptive inputs evoked by laser heat stimuli. Sixteen healthy volunteers (8 F, 8 M; age: 25.5 ± 4.3) were recruited to participate in one session during which painful laser stimuli were applied to their hands with 2 Nd:YAP laser systems. Electroencephalographic activity was recorded to measure laser-evoked potentials and event-related spectral perturbations. Twenty nociceptive stimuli were applied in each of the 4 counterbalanced conditions: (1) right hand, (2) left hand, and both hands with (3) attention to the right or (4) attention to the left. Compared with unilateral conditions, N2 and P2 peak amplitude as well as gamma oscillation power were decreased in bilateral conditions (P < 0.05), but these effects were not affected by the direction of attention (P > 0.1). By contrast, pain was not significantly different in any condition (P > 0.05). These findings show that although more nociceptive inputs reach the brain with multiple nociceptive stimuli, their sensory representation is decreased while pain perception remains unchanged. These interactions between cerebral processing of nociceptive information from different body regions could support coordinated behavioral responses when pain origins from multiple sources. © 2018 International Association for the Study of Pain.

Type de document: Article
Mots-clés libres: concurrent stimulation cortical integration laser-evoked potentials nociception pain time-frequency adult article attention brain clinical article controlled study female hand heat human laser evoked potential male oscillation stimulus volunteer adolescent adverse device effect brain cortex brain mapping electroencephalography laser normal human pain measurement pain threshold pathology pathophysiology physiology time factor young adult cerebral cortex healthy volunteers humans lasers pain perception time factors
Date de dépôt: 26 avr. 2021 20:03
Dernière modification: 26 avr. 2021 20:03
Version du document déposé: Post-print (version corrigée et acceptée)
URI: http://depot-e.uqtr.ca/id/eprint/9582

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