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Regulation of cortical blood flow responses by the nucleus basalis of Meynert during nociceptive processing

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Paquette, Thierry et Tokunaga, Ryota et Touj, Sara et Leblond, Hugues et Piché, Mathieu (2019). Regulation of cortical blood flow responses by the nucleus basalis of Meynert during nociceptive processing. Neuroscience Research, 149 . p. 22-28. ISSN 0168-0102 DOI 10.1016/j.neures.2019.01.008

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Résumé

Cerebral blood flow (CBF) is essential for neuronal metabolic functions. CBF is partly regulated by cholinergic projections from the nucleus basalis of Meynert (NBM) during cortical processing of sensory information. During pain-related processing, however, this mechanism may be altered by large fluctuations in systemic mean arterial pressure (MAP). The objective of this study was to investigate the contribution of NBM to CBF responses evoked by nociceptive electrical stimuli and how it may be affected by systemic MAP. CBF was recorded in isoflurane-anesthetized rats (n = 8) using laser speckle contrast imaging, in two conditions (intact vs left NBM lesion). Electrical stimulation was applied to the sciatic nerve. Sciatic stimulation produced intensity dependent increases in MAP (p < 0.001) that were almost identical between conditions (intact vs left NBM lesion; p = 0.96). In both conditions, sciatic stimulation produced intensity dependent CBF increases (p < 0.001). After NBM lesion, CBF responses were decreased in the left somatosensory cortex ipsilateral to NBM lesion (p = 0.02) but not in the right somatosensory cortex (p = 0.46). These results indicate that NBM contributes to CBF responses to nociceptive stimulation in the ipsilateral, but not contralateral somatosensory cortex and that CBF response attenuation by NBM lesion is not compensated passively by systemic MAP changes. This highlights the importance of NBM's integrity for pain-related hemodynamic responses in the somatosensory cortex. © 2019 Elsevier B.V. and Japan Neuroscience Society

Type de document: Article
Mots-clés libres: basal forebrain cerebral blood flow laser speckle contrast imaging nociception nucleus basalis of Meynert pain isoflurane acetylcholine animal experiment article brain blood flow bregma contrast enhancement controlled study electrostimulation experiment frontal cortex hemodynamics left hemisphere male mean arterial pressure Meynert basal nucleus neuroimaging nociceptive stimulation nonhuman priority journal rat sciatic nerve somatosensory cortex somatosensory evoked potential animal blood pressure brain circulation brain cortex diagnostic imaging pathophysiology physiology procedures vascularization Wistar rat animals basal nucleus of Meynert cerebral cortex cerebrovascular circulation electric stimulation rats rats, Wistar
Date de dépôt: 26 avr. 2021 19:44
Dernière modification: 26 avr. 2021 19:44
Version du document déposé: Post-print (version corrigée et acceptée)
URI: http://depot-e.uqtr.ca/id/eprint/9580

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